methotrexate
/ˌmɛθ.əˈtɹɛkˌseɪt/noun
methotrexate is spelled M-E-T-H-O-T-R-E-X-A-T-E. The wrong spelling people search most is methrotrexate: about 40 Bing searches a month in the United States (September 2025 to August 2026), about 1 in 455 of all searches for the word. Methotrexate is a noun meaning “An antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases, and ectopic…”. The plural of methotrexate is methotrexates.
How many letters and syllables are in methotrexate?
| Letters | 12: M-E-T-H-O-T-R-E-X-A-T-E |
|---|---|
| Syllables | 4 (from its American pronunciation) |
| In writing | about once in every 3 million words; the 54,192nd most frequent word form |
| Wrong spellings searched | 2; the most searched, methrotrexate, about 40 Bing searches a month (all of them) |
Sources: letters and syllables from the English Wiktionary's hyphenation or pronunciation and the CMU Pronouncing Dictionary; written frequency: wordfreq 3.1 (a 2021 snapshot of Wikipedia, subtitles, news, books, web text and social media); Bing searches in the United States: the average month from September 2025 to August 2026 (Microsoft Advertising keyword data through DataForSEO, read September 30, 2026).
How do you spell methotrexate?
Methotrexate is spelled M-E-T-H-O-T-R-E-X-A-T-E. 2 wrong spellings are searched or written often enough to measure; together they are about 1 in 371 of the searches for methotrexate in either form.
Bing searches in the United States: the average month from September 2025 to August 2026 (Microsoft Advertising keyword data through DataForSEO, read September 30, 2026). Wrong spellings are taken from Wiktionary entries tagged "misspelling" and its obsolete or nonstandard forms, Wikipedia's Lists of common misspellings and the codespell dictionary, then measured. The proofreader's marks show the change that corrects each one.
How common is methotrexate?
Methotrexate appears about once in every 3 million words in written English, the 54,192nd most frequent word form in the list.
Source: written frequency: wordfreq 3.1 (a 2021 snapshot of Wikipedia, subtitles, news, books, web text and social media).
How do you pronounce methotrexate?
- UK /ˌmɛθ.əˈtɹɛk.seɪt/
- UK /ˌmiː.θəˈtɹɛk.seɪt/
- US /ˌmɛθ.əˈtɹɛkˌseɪt/
Methotrexate has 4 syllables (counted from its American pronunciation in the CMU Pronouncing Dictionary).
Source: English Wiktionary, dump of September 2, 2026 (CC BY-SA 4.0), through kaikki.org (Wiktextract).
Forms of methotrexate
- methotrexates plural
Source: English Wiktionary, dump of September 2, 2026 (CC BY-SA 4.0), through kaikki.org (Wiktextract).
What does methotrexate mean?
The meanings the English Wiktionary records, quoted as written there (source below).
noun
- 1
An antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases, and ectopic pregnancies.
Source: English Wiktionary, dump of September 2, 2026 (CC BY-SA 4.0), through kaikki.org (Wiktextract).
How do you abbreviate methotrexate?
Wiktionary records one abbreviation of methotrexate: MTX.
Source: English Wiktionary, dump of September 2, 2026 (CC BY-SA 4.0), through kaikki.org (Wiktextract).
Methotrexate in Spanish, French, German and Portuguese
In the sense antimetabolite and antifolate drug:
| Language | Words |
|---|---|
| French | méthotrexate |
| German | Methotrexat |
| Spanish | metotrexato |
Source: English Wiktionary, dump of September 2, 2026 (CC BY-SA 4.0), through kaikki.org (Wiktextract). Translations are Wiktionary's, by sense; a linked word has its own PlainSpell page.
Where does methotrexate come from?
Probably from metho- + tre- (“alteration of pteridine”) + (carbo)x(yl)ate.
Source: English Wiktionary, dump of September 2, 2026 (CC BY-SA 4.0), through kaikki.org (Wiktextract).