serotonergic

/ˌsɛrətəˈnɜːrd͡ʒɪk/

//ˌsɛrətəˈnɜːrd͡ʒɪk// adj

By · According to Wiktionary data (CC BY-SA) ·

"serotonergic" is a 12-letter English headword indexed on PlainSpell.

The verdict

“serotonergic” is uncommon English (frequency #95,398 among 6,566 “S” headwords), classed as an adjective. The kind of spelling people second-guess.

#95,398
frequency rank, English
6,566
“S” headwords

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - Containing or releasing serotonin.

Corpus desk

Index EN-serotonergic · serotonergic · English

serotonergic · rank #95,398 · 0 variants · 0 confusables

  • FREQ-RARE #95,398
  • LEN-MEGA 12 letters
  • VOW-5 5 vowels
  • CONFUS-0 No pairs
  • VAR-0 0 variants
  • BOOK-DENSE 6,566
  • PHOTO-FINISH sensually

Nearest frequency peer: sensually (-1 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Frequency neighbourhood for “serotonergic”

Lower corpus rank = more everyday usage (inverted bar length for readability)

corpus weight

What this shows Bars show where “serotonergic” sits against the nearest ranked English headwords in the FrequencyWords band, not a reprint of letter-browse containment.

Source FrequencyWords open word-frequency list As of September 3, 2026
Key facts for serotonergic
PropertyValue
Headwordserotonergic
LanguageEnglish
Part of speechAdjective
IPA/ˌsɛrətəˈnɜːrd͡ʒɪk/
Letters12
Frequency rank#95,398
Misspellings tracked0
Confusable pairs0
SourceWiktionary (kaikki.org)

Where “serotonergic” sits in English frequency

Word frequency stretches from the small set of words we reach for constantly (left) out to the long tail barely used once in a while (right).serotonergiclands here:

#1#100#1K#10K#100K
← used constantlyrarely used →

The axis is logarithmic, with each marked tick roughly ten times rarer than the last. Same rarity band neighbours include “sensually” (#95,397), “Sers” (#95,399), “sesquicentennial” (#95,400). Source: FrequencyWords open word-frequency list.

Rare enough to double-check

serotonergic is uncommon English at frequency #95,398 among 6,566 “S” headwords, classed as anadjective, transcribed /ˌsɛrətəˈnɜːrd͡ʒɪk/. Rarity is why readers land here mid-draft. 2 senses are on record.

Our edit-distance generator produced no likely misspellings for serotonergic, and the word's spelling is regular enough that our generator found nothing worth flagging. No close-neighbour confusable shows up for this headword in our dataset, since its spelling is unusual enough that it doesn't cluster with a lookalike.

Etymologically, the entry records: From seroton(in) + -ergic. The correct English form is serotonergic, spelled S-E-R-O-T-O-N-E-R-G-I-C.

Definition

  1. 1
    Containing or releasing serotonin.
  2. 2
    Involved in, or capable of modulating activity in, neurotransmission pathways that use serotonin receptor proteins.

Recorded use

Wiktionary example

These source excerpts show how serotonergic appears in context. They illustrate usage; the definition above remains the entry’s reference meaning.

  1. Moreover, the results of multiple administrations of the receptor ligands to control rats indicate that the NPY systems in both structures under study are modulated in the same manner by dopaminergic activity and differentially by adrenergic, N-methyl-D-aspartate and serotonergic activity.

Etymology

From seroton(in) + -ergic.

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "serotonergic"?
"serotonergic" is spelled S-E-R-O-T-O-N-E-R-G-I-C. The IPA pronunciation is /ˌsɛrətəˈnɜːrd͡ʒɪk/.
What does "serotonergic" mean?
As an adjective, "serotonergic" means: Containing or releasing serotonin.
How do you pronounce "serotonergic"?
The IPA (International Phonetic Alphabet) transcription for "serotonergic" is /ˌsɛrətəˈnɜːrd͡ʒɪk/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.
What is the origin of the word "serotonergic"?
From seroton(in) + -ergic. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "serotonergic", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 12 letters (nearest by frequency rank).

protectively#95,304prizefighter#95,298translatable#95,529unappetizing#95,553

What to do next

You've looked up "serotonergic". Here's where to go from here.

  • Usage frequency rank #95,398 among English headwords in this corpus. Corpus statistics
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PlainSpell is a reference corpus, not spelling advice. Verify unusual forms in context.

Data Source

Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list