antihistamine

/ˌæn.tiˈhɪs.tə.miːn/

//ˌæn.tiˈhɪs.tə.miːn// noun

By · According to Wiktionary data (CC BY-SA) ·

"antihistamine" is a 13-letter English headword indexed on PlainSpell.

The verdict

“antihistamine” is uncommon English (frequency #61,958 among 3,931 “A” headwords), classed as a noun. The kind of spelling people second-guess.

#61,958
frequency rank, English
3,931
“A” headwords

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - A drug or substance that counteracts the effects of a histamine. Commonly used to alleviate the symptoms of hay fever and other allergies.

Corpus desk

Index EN-antihistamine · antihistamine · English

antihistamine · rank #61,958 · 0 variants · 0 confusables

  • FREQ-RARE #61,958
  • LEN-MEGA 13 letters
  • VOW-6 6 vowels
  • CONFUS-0 No pairs
  • VAR-0 0 variants
  • BOOK-MID 3,931
  • PHOTO-FINISH animes

Nearest frequency peer: animes (-1 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Long-tail ranks near “antihistamine”

Sparse band: bars invert rank so rarer forms read shorter

corpus weight

What this shows Long-tail view: where “antihistamine” sits against similarly uncommon English ranks.

Source FrequencyWords open word-frequency list As of September 3, 2026
Key facts for antihistamine
PropertyValue
Headwordantihistamine
LanguageEnglish
Part of speechNoun
IPA/ˌæn.tiˈhɪs.tə.miːn/
Letters13
Frequency rank#61,958
Misspellings tracked0
Confusable pairs0
SourceWiktionary (kaikki.org)

Long-tail rank of “antihistamine” in English

Every-word frequency runs from the handful of words we use constantly (left) to the long tail used once in a blue moon (right).antihistaminefalls in this rarity band:

#1#100#1K#10K#100K
← used constantlyrarely used →

Ticks step logarithmically, so each one marks a roughly tenfold drop in how often the word turns up. Rare peers in the same band: “animes” (#61,957), “aplomb” (#61,959), “andor” (#61,956). Among 3,931 “A” headwords, “antihistamine” is #61,958. Source: FrequencyWords open word-frequency list.

Rare enough to double-check

antihistamine is uncommon English at frequency #61,958 among 3,931 “A” headwords, classed as anoun, transcribed /ˌæn.tiˈhɪs.tə.miːn/. Rarity is why readers land here mid-draft. Gloss: "A drug or substance that counteracts the effects of a histamine. Commonly used to alleviate the symptoms of hay fever and other allergies.".

antihistamine doesn't appear in our generated misspelling index, since its letter sequence doesn't invite the usual edit-distance slips. No close-neighbour confusable shows up for this headword in our dataset, a sign it's visually distinctive enough not to be mixed up with another word.

Etymologically, the entry records: From anti- + histamine. The correct English form is antihistamine, spelled A-N-T-I-H-I-S-T-A-M-I-N-E.

Definition

  1. 1
    A drug or substance that counteracts the effects of a histamine. Commonly used to alleviate the symptoms of hay fever and other allergies.

Recorded use

Wiktionary example

These source excerpts show how antihistamine appears in context. They illustrate usage; the definition above remains the entry’s reference meaning.

  1. Perhaps the most striking method of demonstrating the effect of antihistamine substances is to use them to protect guinea-pigs against the action of histamine sprayed into the air from an atomizer.

Etymology

From anti- + histamine.

Synonyms

antihistamineantihistaminic

This word in other languages

antihistamínico(Español)antihistaminique(Français)Antihistaminikum(Deutsch)

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "antihistamine"?
"antihistamine" is spelled A-N-T-I-H-I-S-T-A-M-I-N-E. The IPA pronunciation is /ˌæn.tiˈhɪs.tə.miːn/.
What does "antihistamine" mean?
As a noun, "antihistamine" means: A drug or substance that counteracts the effects of a histamine. Commonly used to alleviate the symptoms of hay fever and other allergies.
How do you pronounce "antihistamine"?
The IPA (International Phonetic Alphabet) transcription for "antihistamine" is /ˌæn.tiˈhɪs.tə.miːn/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.
What is the origin of the word "antihistamine"?
From anti- + histamine. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "antihistamine", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 13 letters (nearest by frequency rank).

transmissible#61,873quadrilateral#61,741insubstantial#62,224nonconformist#61,666

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list