spironolactone
/ˌspʌɪ.ɹən.ə(ʊ)ˈlæk.təʊn/
"spironolactone" is a 14-letter English headword indexed on PlainSpell.
The verdict
“spironolactone” is uncommon English (frequency #75,438 among 54,294 “S” headwords), classed as a noun. The kind of spelling people second-guess.
- #75,438
- frequency rank, English
- 54,294
- “S” headwords
According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - A steroid drug which acts as an antimineralocorticoid (for which purpose it is used in the treatment of certain types of edema and hypertension) and an antiandrogen (for which purpose it is used as...
| Property | Value |
|---|---|
| Headword | spironolactone |
| Language | English |
| Part of speech | Noun |
| IPA | /ˌspʌɪ.ɹən.ə(ʊ)ˈlæk.təʊn/ |
| Letters | 14 |
| Frequency rank | #75,438 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Where “spironolactone” sits in English frequency
Rare enough to double-check
spironolactone is uncommon English at frequency #75,438 among 54,294 “S” headwords, classed as anoun, transcribed /ˌspʌɪ.ɹən.ə(ʊ)ˈlæk.təʊn/. Rarity is why readers land here mid-draft. Gloss: "A steroid drug which acts as an antimineralocorticoid (for which purpose it is used in the treatment of certain types of edema and hypertension) and an antiandrogen (for which purpose it is used as...".
No generated misspelling entries exist for spironolactone in our index, and the word's spelling is regular enough that our generator found nothing worth flagging. No confusable counterpart is on file for this word, since nothing in our dataset looks or sounds close enough to cause mix-ups.
Etymologically, the entry records: From spiro + -one + -o- + lactone. The correct English form is spironolactone, spelled S-P-I-R-O-N-O-L-A-C-T-O-N-E.
Definition
- 1A steroid drug which acts as an antimineralocorticoid (for which purpose it is used in the treatment of certain types of edema and hypertension) and an antiandrogen (for which purpose it is used as part of some types of hormone therapy, especially for transgender women).
Etymology
From spiro + -one + -o- + lactone.
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
How do you spell "spironolactone"?
What does "spironolactone" mean?
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Using “spironolactone”
The practical upshot for anyone who landed here from a spell-check.
- The one correct English spelling is S-P-I-R-O-N-O-L-A-C-T-O-N-E - every other letter order is a misspelling in standard orthography.
- Say it as /ˌspʌɪ.ɹən.ə(ʊ)ˈlæk.təʊn/ (IPA); tap the speaker on the pronunciation badge to hear it where audio exists.
- Browse more English words and confusable pairs in the same reference. English words
Other uncommon English words near this rank
Data Source
Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.