serine

noun

By · According to Wiktionary data (CC BY-SA) ·

"serine" is a 6-letter English headword indexed on PlainSpell.

The verdict

“serine” has 8 generated spelling variants in the English index at frequency #45,078. The variants make it a useful spelling check.

#45,078
frequency rank, English
6,566
“S” headwords
8
tracked misspellings
20
confusable pairs

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - A nonessential amino acid, CH₂OH.CH(NH₂)COOH, found in most animal proteins, notably silk.

Corpus desk

Index EN-serine · serine · English

serine · rank #45,078 · 8 variants · 20 confusables

  • FREQ-MID #45,078
  • LEN-LONG 6 letters
  • VOW-3 3 vowels
  • CONFUS-HIGH 20 pairs
  • VAR-MID 8 variants
  • BOOK-DENSE 6,566
  • PHOTO-FINISH serif

Nearest frequency peer: serif (-1 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Rank peers near misspelling magnet “serine”

Same rarity band: useful when a typo lands on a peer headword

corpus weight

What this shows “serine” sits among these FrequencyWords peers; misspelling depth is tracked separately in the edit-distance chart.

Source FrequencyWords open word-frequency list As of September 3, 2026

Visual similarity to commonly confused words

How many letter changes separate each confused pair (Levenshtein distance, normalized).

serine vs sine
67% similar
serine vs serve
67% similar
serine vs shine
67% similar

Source: PlainSpell confusable corpus (Wiktionary, CC BY-SA).

Key facts for serine
PropertyValue
Headwordserine
LanguageEnglish
Part of speechNoun
Letters6
Frequency rank#45,078
Misspellings tracked8
Confusable pairs20
SourceWiktionary (kaikki.org)

Frequency seat of misspelling magnet “serine”

Word frequency stretches from the small set of words we reach for constantly (left) out to the long tail barely used once in a while (right).serinelands here:

#1#100#1K#10K#100K
← used constantlyrarely used →

Ticks step logarithmically, so each one marks a roughly tenfold drop in how often the word turns up. Same rarity band neighbours include “serif” (#45,077), “selfishly” (#45,076), “Shaheen” (#45,080). Among 6,566 “S” headwords, “serine” is #45,078. Source: FrequencyWords open word-frequency list.

A misspelling magnet

The generator records 8 spelling variants around serine, anoun. Corpus frequency is #45,078 among 6,566 “S” headwords. Dominant gloss: "A nonessential amino acid, CH₂OH.CH(NH₂)COOH, found in most animal proteins, notably silk.".

Our generated misspelling index lists 8 likely wrong-spelling variants for serine, with forms such as "esrine", "seirne", and "serien". Each of these forms differs from the correct spelling by one small edit: a doubled letter, a dropped silent letter, or a substituted vowel. It also participates in 20 confusable-pair relationships, "sine", "serve", "shine", and more, where similar look or sound leads writers to substitute one word for another in context.

Etymologically, the entry records: From Latin sericus (“silken”). The compound was first obtained from silk protein, a particularly rich source, in 1865. See also serge. The correct English form is serine, spelled S-E-R-I-N-E.

Definition

  1. 1
    A nonessential amino acid, CH₂OH.CH(NH₂)COOH, found in most animal proteins, notably silk.

Etymology

From Latin sericus (“silken”). The compound was first obtained from silk protein, a particularly rich source, in 1865. See also serge.

This word in other languages

serina(Español)sérine(Français)Serin(Deutsch)

Common misspellings

Also misspelled as:

  • esrine
  • seirne
  • serien
  • serinne
  • sernie
  • serrine
  • sreine
  • sserine

Misspelling Pattern Breakdown

How far each generated variant is from the correct spelling of serine - expressed in single-character edits (insert, delete, or swap one letter). Bigger bars stand out at a glance; a one-edit slip is the hardest to catch.

esrine2seirne2serien2serinne1sernie2serrine1sreine2sserine1
Edit distance from "serine"

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "serine"?
"serine" is spelled S-E-R-I-N-E.
What does "serine" mean?
As a noun, "serine" means: A nonessential amino acid, CH₂OH.CH(NH₂)COOH, found in most animal proteins, notably silk.
What words are commonly confused with "serine"?
"serine" is commonly confused with "sine", "serve", "shine". These words look or sound similar but have different meanings. PlainSpell provides detailed comparisons for each pair.
What is the origin of the word "serine"?
From Latin sericus (“silken”). The compound was first obtained from silk protein, a particularly rich source, in 1865. See also serge. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "serine", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 6 letters (nearest by frequency rank).

Seguin#45,075Simcoe#45,086Sallie#45,068snazzy#45,089

Similar misspelling depth

Headwords with a similar count of attested misspellings (8 here; floor ≥5).

spiny8 variantssudoku8 variantsrepute8 variantstangy8 variants

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list