sepsis

/ˈsɛpsɪs/

//ˈsɛpsɪs// noun

"sepsis" is a 6-letter English headword indexed on PlainSpell.

The verdict

“sepsis” has 9 generated spelling variants in the English index at frequency #28,714. The variants make it a useful spelling check.

#28,714
frequency rank, English
6,566
“S” headwords
9
tracked misspellings
5
confusable pairs

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - A serious medical condition in which the whole body is inflamed, causing injury to its own tissues and organs as a response to infection.

Corpus desk

Index EN-sepsis · sepsis · English

sepsis · rank #28,714 · 9 variants · 5 confusables

  • FREQ-MID #28,714
  • LEN-LONG 6 letters
  • VOW-2 2 vowels
  • CONFUS-MID 5 pairs
  • VAR-MID 9 variants
  • BOOK-DENSE 6,566
  • PHOTO-FINISH seer

Nearest frequency peer: seer (-1 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Rank peers near misspelling magnet “sepsis”

Same rarity band: useful when a typo lands on a peer headword

corpus weight

What this shows “sepsis” sits among these FrequencyWords peers; misspelling depth is tracked separately in the edit-distance chart.

Source FrequencyWords open word-frequency list As of September 3, 2026

Visual similarity to commonly confused words

How many letter changes separate each confused pair (Levenshtein distance, normalized).

sepsis vs septic
67% similar
sepsis vs stasis
67% similar
sepsis vs semis
67% similar

Source: PlainSpell confusable corpus (Wiktionary, CC BY-SA).

Key facts for sepsis
PropertyValue
Headwordsepsis
LanguageEnglish
Part of speechNoun
IPA/ˈsɛpsɪs/
Letters6
Frequency rank#28,714
Misspellings tracked9
Confusable pairs5
SourceWiktionary (kaikki.org)

Frequency seat of misspelling magnet “sepsis”

Every-word frequency runs from the handful of words we use constantly (left) to the long tail used once in a blue moon (right).sepsislands here:

#1#100#1K#10K#100K
← used constantlyrarely used →

Scale is logarithmic (each tick is 10× rarer). Same rarity band neighbours include “seer” (#28,713), “Seward” (#28,715), “scrubbed” (#28,712). Among 6,566 “S” headwords, “sepsis” is #28,714. Source: FrequencyWords open word-frequency list.

A misspelling magnet

The generator records 9 spelling variants around sepsis (IPA /ˈsɛpsɪs/), anoun. Corpus frequency is #28,714 among 6,566 “S” headwords. Dominant gloss: "A serious medical condition in which the whole body is inflamed, causing injury to its own tissues and organs as a response to infection.".

Our generated misspelling index lists 9 likely wrong-spelling variants for sepsis, with forms such as "espsis", "sepiss", and "seppsis". Every one of these variants traces to a single-character edit -- an added or dropped letter, a swapped consonant, or a vowel swap -- the kind of slip a spell-checker is built to catch. It also participates in 5 confusable-pair relationships, "septic", "stasis", "semis", and more, a pairing that trips writers up because the two words share enough sound or shape to blur together.

Etymologically, the entry records: coined by Hippocrates From Ancient Greek σῆψις (sêpsis, “putrefaction”), from σήπειν (sḗpein, “to make rotten”), from σήψ (sḗps, “a kind of lizard; also a kind of serpent whose bite was alleged to cause putrefaction”). The correct English form is sepsis, spelled S-E-P-S-I-S.

Definition

  1. 1
    A serious medical condition in which the whole body is inflamed, causing injury to its own tissues and organs as a response to infection.

Recorded use

Wiktionary example

These source excerpts show how sepsis appears in context. They illustrate usage; the definition above remains the entry’s reference meaning.

  1. Imagine the sepsis of helpless loathing [Jimmy Connors] must have inspired in his opponents during his "great runs" at the US Open.

Etymology

coined by Hippocrates From Ancient Greek σῆψις (sêpsis, “putrefaction”), from σήπειν (sḗpein, “to make rotten”), from σήψ (sḗps, “a kind of lizard; also a kind of serpent whose bite was alleged to cause putrefaction”).

This word in other languages

Common misspellings

Also misspelled as:

  • espsis
  • sepiss
  • seppsis
  • sepsiss
  • sepssi
  • sepssis
  • sespis
  • spesis
  • ssepsis

Misspelling Pattern Breakdown

How far each generated variant is from the correct spelling of sepsis - counted as single-character edits (an insertion, a deletion, or a substituted letter). The larger the bar, the easier the typo is to spot; one-edit slips are the ones that sneak past readers.

espsis2sepiss2seppsis1sepsiss1sepssi2sepssis1sespis2spesis2
Edit distance from "sepsis"

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "sepsis"?
"sepsis" is spelled S-E-P-S-I-S. The IPA pronunciation is /ˈsɛpsɪs/.
What does "sepsis" mean?
As a noun, "sepsis" means: A serious medical condition in which the whole body is inflamed, causing injury to its own tissues and organs as a response to infection.
What words are commonly confused with "sepsis"?
"sepsis" is commonly confused with "septic", "stasis", "semis". These words look or sound similar but have different meanings. PlainSpell provides detailed comparisons for each pair.
How do you pronounce "sepsis"?
The IPA (International Phonetic Alphabet) transcription for "sepsis" is /ˈsɛpsɪs/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.
What is the origin of the word "sepsis"?
coined by Hippocrates From Ancient Greek σῆψις (sêpsis, “putrefaction”), from σήπειν (sḗpein, “to make rotten”), from σήψ (sḗps, “a kind of lizard; also a kind of serpent whose bite was alleged to cause putrefaction”). See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "sepsis", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 6 letters (nearest by frequency rank).

Similar misspelling depth

Headwords with a similar count of attested misspellings (9 here; floor ≥5).

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list