reuptake

noun

"reuptake" is a 8-letter English headword indexed on PlainSpell.

The verdict

“reuptake” is uncommon English (frequency #58,978 among 3,094 “R” headwords), classed as a noun. The kind of spelling people second-guess.

#58,978
frequency rank, English
3,094
“R” headwords

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - A second or subsequent uptake.

Corpus desk

Index EN-reuptake · reuptake · English

reuptake · rank #58,978 · 0 variants · 0 confusables

  • FREQ-RARE #58,978
  • LEN-LONG 8 letters
  • VOW-4 4 vowels
  • CONFUS-0 No pairs
  • VAR-0 0 variants
  • BOOK-MID 3,094
  • PHOTO-FINISH reroute

Nearest frequency peer: reroute (-2 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Long-tail ranks near “reuptake”

Sparse band: bars invert rank so rarer forms read shorter

corpus weight

What this shows Long-tail view: where “reuptake” sits against similarly uncommon English ranks.

Source FrequencyWords open word-frequency list As of September 3, 2026
Key facts for reuptake
PropertyValue
Headwordreuptake
LanguageEnglish
Part of speechNoun
Letters8
Frequency rank#58,978
Misspellings tracked0
Confusable pairs0
SourceWiktionary (kaikki.org)

Long-tail rank of “reuptake” in English

Every-word frequency runs from the handful of words we use constantly (left) to the long tail used once in a blue moon (right).reuptakefalls in this rarity band:

#1#100#1K#10K#100K
← used constantlyrarely used →

Ticks step logarithmically, so each one marks a roughly tenfold drop in how often the word turns up. Rare peers in the same band: “reroute” (#58,976), “rickets” (#58,980), “RER” (#58,975). Among 3,094 “R” headwords, “reuptake” is #58,978. Source: FrequencyWords open word-frequency list.

Rare enough to double-check

reuptake is uncommon English at frequency #58,978 among 3,094 “R” headwords, classed as anoun. Rarity is why readers land here mid-draft. 2 senses are on record.

reuptake has no tracked misspelling variants, which points to an orthography that plays by predictable English rules. We don't track a confusable pairing for this entry, which tends to mean the word is visually distinctive enough to stand on its own.

Etymologically, the entry records: From re- + uptake. The correct English form is reuptake, spelled R-E-U-P-T-A-K-E.

Definition

  1. 1
    A second or subsequent uptake.
  2. 2
    Specifically, the reabsorption of a neurotransmitter by a neuron after the transmission of a neural impulse across a synapse.

Recorded use

Wiktionary example

These source excerpts show how reuptake appears in context. They illustrate usage; the definition above remains the entry’s reference meaning.

  1. The class of antidepressants most commonly associated with sexual dysfunction is selective serotonin reuptake inhibitors, or SSRIs, which treat depression by ultimately increasing levels of the neurotransmitter serotonin in the brain.

Etymology

From re- + uptake.

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "reuptake"?
"reuptake" is spelled R-E-U-P-T-A-K-E.
What does "reuptake" mean?
As a noun, "reuptake" means: A second or subsequent uptake.
What is the origin of the word "reuptake"?
From re- + uptake. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "reuptake", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 8 letters (nearest by frequency rank).

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list