nuclease
"nuclease" is a 8-letter English headword indexed on PlainSpell.
The verdict
“nuclease” is uncommon English (frequency #95,199 among 24,391 “N” headwords), classed as a noun. The kind of spelling people second-guess.
- #95,199
- frequency rank, English
- 24,391
- “N” headwords
According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.
| Property | Value |
|---|---|
| Headword | nuclease |
| Language | English |
| Part of speech | Noun |
| Letters | 8 |
| Frequency rank | #95,199 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Where “nuclease” sits in English frequency
Rare enough to double-check
nuclease is uncommon English at frequency #95,199 among 24,391 “N” headwords, classed as anoun. Rarity is why readers land here mid-draft. Gloss: "Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.".
Zero misspellings are on record for nuclease in our index, since its letter pattern doesn't lend itself to common typo substitutions. It is not paired with a close-neighbour confusable in our dataset, suggesting its spelling stands apart enough that readers rarely confuse it with something else.
Etymologically, the entry records: From nucleo- + -ase. The correct English form is nuclease, spelled N-U-C-L-E-A-S-E.
Definition
- 1Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.
Etymology
From nucleo- + -ase.
This word in other languages
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
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Using “nuclease”
The practical upshot for anyone who landed here from a spell-check.
- The one correct English spelling is N-U-C-L-E-A-S-E - every other letter order is a misspelling in standard orthography.
- Browse more English words and confusable pairs in the same reference. English words
Other uncommon English words near this rank
Data Source
Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.