nuclease
"nuclease" is a 8-letter English headword indexed on PlainSpell.
The verdict
“nuclease” is uncommon English (frequency #95,199 among 1,534 “N” headwords), classed as a noun. The kind of spelling people second-guess.
- #95,199
- frequency rank, English
- 1,534
- “N” headwords
According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.
Corpus desk
Index EN-nuclease · nuclease · English
nuclease · rank #95,199 · 0 variants · 0 confusables
- FREQ-RARE #95,199
- LEN-LONG 8 letters
- VOW-4 4 vowels
- CONFUS-0 No pairs
- VAR-0 0 variants
- BOOK-MID 1,534
- PHOTO-FINISH numinous
Nearest frequency peer: numinous (+1 rank slots)
Read with this headword: Spelling guide for this pattern
Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.
Long-tail ranks near “nuclease”
Sparse band: bars invert rank so rarer forms read shorter
- nole
nole
4,807 corpus weight
- novation
novation
4,804 corpus weight
- nuclease
nuclease
4,802 corpus weight
- numinous
numinous
4,801 corpus weight
- nuthatch
nuthatch
4,799 corpus weight
- OAG
OAG
4,796 corpus weight
What this shows Long-tail view: where “nuclease” sits against similarly uncommon English ranks.
| Property | Value |
|---|---|
| Headword | nuclease |
| Language | English |
| Part of speech | Noun |
| Letters | 8 |
| Frequency rank | #95,199 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Long-tail rank of “nuclease” in English
Rare enough to double-check
nuclease is uncommon English at frequency #95,199 among 1,534 “N” headwords, classed as anoun. Rarity is why readers land here mid-draft. Gloss: "Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.".
Zero misspellings are on record for nuclease in our index, since its letter pattern doesn't lend itself to common typo substitutions. It is not paired with a close-neighbour confusable in our dataset, suggesting its spelling stands apart enough that readers rarely confuse it with something else.
Etymologically, the entry records: From nucleo- + -ase. The correct English form is nuclease, spelled N-U-C-L-E-A-S-E.
Definition
- 1Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.
Etymology
From nucleo- + -ase.
This word in other languages
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
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Similar English words by spelling shape
Same letter count and similar misspelling depth for "nuclease", not the corpus desk frequency band.
Same letter count
Frequency-ranked English headwords with 8 letters (nearest by frequency rank).