hydrolase

/ˈhaɪdɹəleɪz/

//ˈhaɪdɹəleɪz// noun

By · According to Wiktionary data (CC BY-SA) ·

"hydrolase" is a 9-letter English headword indexed on PlainSpell.

The verdict

“hydrolase” is uncommon English (frequency #97,127 among 23,837 “H” headwords), classed as a noun. The kind of spelling people second-guess.

#97,127
frequency rank, English
23,837
“H” headwords

According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - An enzyme that catalyzes the hydrolysis of a substrate.

Key facts for hydrolase
PropertyValue
Headwordhydrolase
LanguageEnglish
Part of speechNoun
IPA/ˈhaɪdɹəleɪz/
Letters9
Frequency rank#97,127
Misspellings tracked0
Confusable pairs0
SourceWiktionary (kaikki.org)

Where “hydrolase” sits in English frequency

Every-word frequency runs from the handful of words we use constantly (left) to the long tail used once in a blue moon (right). hydrolase lands here:

#1#100#1K#10K#100K
← used constantlyrarely used →

Scale is logarithmic (each tick is 10× rarer). Source: FrequencyWords open word-frequency list.

Rare enough to double-check

hydrolase is uncommon English at frequency #97,127 among 23,837 “H” headwords, classed as anoun, transcribed /ˈhaɪdɹəleɪz/. Rarity is why readers land here mid-draft. Gloss: "An enzyme that catalyzes the hydrolysis of a substrate.".

We couldn't generate a plausible misspelling set for hydrolase, since its letter pattern doesn't lend itself to common typo substitutions. This entry stands alone in our confusable dataset, a sign it's visually distinctive enough not to be mixed up with another word.

Etymologically, the entry records: From hydrolysis + -ase. The correct English form is hydrolase, spelled H-Y-D-R-O-L-A-S-E.

Definition

  1. 1
    An enzyme that catalyzes the hydrolysis of a substrate.

Etymology

From hydrolysis + -ase.

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "hydrolase"?
"hydrolase" is spelled H-Y-D-R-O-L-A-S-E. The IPA pronunciation is /ˈhaɪdɹəleɪz/.
What does "hydrolase" mean?
As a noun, "hydrolase" means: An enzyme that catalyzes the hydrolysis of a substrate.
How do you pronounce "hydrolase"?
The IPA (International Phonetic Alphabet) transcription for "hydrolase" is /ˈhaɪdɹəleɪz/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.
What is the origin of the word "hydrolase"?
From hydrolysis + -ase. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Using “hydrolase”

The practical upshot for anyone who landed here from a spell-check.

  • The one correct English spelling is H-Y-D-R-O-L-A-S-E - every other letter order is a misspelling in standard orthography.
  • Say it as /ˈhaɪdɹəleɪz/ (IPA); tap the speaker on the pronunciation badge to hear it where audio exists.
  • Browse more English words and confusable pairs in the same reference. English words

Other uncommon English words near this rank

Data Source

Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list FrequencyWords open word-frequency list