guanine
/ˈɡwɑː.niːn/
"guanine" is a 7-letter English headword indexed on PlainSpell.
The verdict
“guanine” is uncommon English (frequency #66,698 among 18,276 “G” headwords), classed as a noun. The kind of spelling people second-guess.
- #66,698
- frequency rank, English
- 18,276
- “G” headwords
According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - A substance first obtained from guano; it is a nucleic base and pairs with cytosine in DNA and RNA (by means of three hydrogen bonds).
| Property | Value |
|---|---|
| Headword | guanine |
| Language | English |
| Part of speech | Noun |
| IPA | /ˈɡwɑː.niːn/ |
| Letters | 7 |
| Frequency rank | #66,698 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Where “guanine” sits in English frequency
Rare enough to double-check
guanine is uncommon English at frequency #66,698 among 18,276 “G” headwords, classed as anoun, transcribed /ˈɡwɑː.niːn/. Rarity is why readers land here mid-draft. Gloss: "A substance first obtained from guano; it is a nucleic base and pairs with cytosine in DNA and RNA (by means of three hydrogen bonds).".
No generated misspelling entries exist for guanine in our index, a sign its spelling follows regular English conventions. No confusable counterpart is on file for this word, since its spelling is unusual enough that it doesn't cluster with a lookalike.
Etymologically, the entry records: From guano + -ine. Guanine was named by the German chemist Julius Bodo Unger in 1846 who isolated it from guano. The correct English form is guanine, spelled G-U-A-N-I-N-E.
Definition
- 1A substance first obtained from guano; it is a nucleic base and pairs with cytosine in DNA and RNA (by means of three hydrogen bonds).
Etymology
From guano + -ine. Guanine was named by the German chemist Julius Bodo Unger in 1846 who isolated it from guano.
This word in other languages
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
How do you spell "guanine"?
What does "guanine" mean?
How do you pronounce "guanine"?
What is the origin of the word "guanine"?
Is PlainSpell free to use?
Using “guanine”
The practical upshot for anyone who landed here from a spell-check.
- The one correct English spelling is G-U-A-N-I-N-E - every other letter order is a misspelling in standard orthography.
- Say it as /ˈɡwɑː.niːn/ (IPA); tap the speaker on the pronunciation badge to hear it where audio exists.
- Browse more English words and confusable pairs in the same reference. English words
Other uncommon English words near this rank
Data Source
Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.