enzyme

Name: enzyme, English Word Data
Creator: Wiktionary
License: https://creativecommons.org/licenses/by-sa/4.0/

/ˈɛn.zaɪm/

//ˈɛn.zaɪm// noun

By PlainSpell · According to Wiktionary data (CC BY-SA) · analyzed September 3, 2026

The verdict

“enzyme” has 9 generated spelling variants in the English index at frequency #9,329. The variants make it a useful spelling check.

#9,329
frequency rank, English: 2,246
“E” headwords: 9
tracked misspellings

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - A biomolecule that catalyses a biological chemical reaction: either a globular protein with this function or an RNA molecule with this function.

Corpus desk

Index EN-enzyme · enzyme · English

enzyme · rank #9,329 · 9 variants · 0 confusables

FREQ-COMMON #9,329
LEN-LONG 6 letters
VOW-3 3 vowels
CONFUS-0 No pairs
VAR-MID 9 variants
BOOK-MID 2,246
PHOTO-FINISH endure

Nearest frequency peer: endure (-1 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Eden

90,676
electron

90,674
endure

90,673
enzyme

90,672
evolutionary

90,671
fellows

90,668

What this shows “enzyme” sits among these FrequencyWords peers; misspelling depth is tracked separately in the edit-distance chart.

Key facts for enzyme
Property	Value
Headword	enzyme
Language	English
Part of speech	Noun
IPA	/ˈɛn.zaɪm/
Letters	6
Frequency rank	#9,329
Misspellings tracked	9
Confusable pairs	0
Source	Wiktionary (kaikki.org)

Frequency seat of misspelling magnet “enzyme”

Every-word frequency runs from the handful of words we use constantly (left) to the long tail used once in a blue moon (right).enzymelands here:

#9,329

#1#100#1K#10K#100K

← used constantlyrarely used →

Scale is logarithmic (each tick is 10× rarer). Same rarity band neighbours include “endure” (#9,328), “evolutionary” (#9,330), “electron” (#9,327). Among 2,246 “E” headwords, “enzyme” is #9,329. Source: FrequencyWords open word-frequency list.

A misspelling magnet

The generator records 9 spelling variants around enzyme (IPA /ˈɛn.zaɪm/), anoun. Corpus frequency is #9,329 among 2,246 “E” headwords. Wiktionary lists 3 senses, so context still picks the gloss.

Our generated misspelling index lists 9 likely wrong-spelling variants for enzyme, with forms such as "ennzyme", "enyzme", and "enzmye". Each variant is a distinct typo pattern an edit-distance generator flags, typically a doubled-consonant error, a silent-letter drop, or a vowel substitution. No close-neighbour confusable shows up for this headword in our dataset, which typically means the spelling is too distinctive to be mistaken for another word.

Etymologically, the entry records: From German Enzym, coined 1878 by the German physiologist Wilhelm Kühne from Ancient Greek ἐν (en, “in”) + ζύμη (zúmē, “leaven”). By surface analysis, en- + zyme. The correct English form is enzyme, spelled E-N-Z-Y-M-E.

Definition

1
A biomolecule that catalyses a biological chemical reaction: either a globular protein with this function or an RNA molecule with this function.
2
A biomolecule that catalyses a biological chemical reaction: either a globular protein with this function or an RNA molecule with this function.
3
Leavened bread, as opposed to azyme.

Etymology

From German Enzym, coined 1878 by the German physiologist Wilhelm Kühne from Ancient Greek ἐν (en, “in”) + ζύμη (zúmē, “leaven”). By surface analysis, en- + zyme.

This word in other languages

enzima(Español)enzyme(Français)Enzym(Deutsch)

Common misspellings

Also misspelled as:

ennzyme
enyzme
enzmye
enzyem
enzymme
enzyyme
enzzyme
eznyme
nezyme

Misspelling Pattern Breakdown

How far each generated variant is from the correct spelling of enzyme - counted as single-character edits (an insertion, a deletion, or a substituted letter). The larger the bar, the easier the typo is to spot; one-edit slips are the ones that sneak past readers.

Edit distance from "enzyme"

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "enzyme"?

"enzyme" is spelled E-N-Z-Y-M-E. The IPA pronunciation is /ˈɛn.zaɪm/.

What does "enzyme" mean?

As a noun, "enzyme" means: A biomolecule that catalyses a biological chemical reaction: either a globular protein with this function or an RNA molecule with this function.

What are common misspellings of "enzyme"?

Common misspellings include "ennzyme", "enyzme", "enzmye", "enzyem", "enzymme". The correct spelling is "enzyme".

How do you pronounce "enzyme"?

The IPA (International Phonetic Alphabet) transcription for "enzyme" is /ˈɛn.zaɪm/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.

What is the origin of the word "enzyme"?

From German Enzym, coined 1878 by the German physiologist Wilhelm Kühne from Ancient Greek ἐν (en, “in”) + ζύμη (zúmē, “leaven”). By surface analysis, en- + zyme. See the full etymology section above for more details.

Is PlainSpell free to use?

Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "enzyme", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 6 letters (nearest by frequency rank).

endure#9,328 Fraser#9,335 hacked#9,341 decree#9,316

Similar misspelling depth

Headwords with a similar count of attested misspellings (9 here; floor ≥5).

fellows9 variants confess9 variants joints9 variants cheeks9 variants