CRISPR

/ˈkrɪspər/

//ˈkrɪspər// noun

"crispr" is a 6-letter English headword indexed on PlainSpell.

The verdict

“CRISPR” is a moderately-common English word, ranked #44,144 in English word frequency and used as a noun.

#44,144
frequency rank, English
6
letters
10
tracked misspellings
11
confusable pairs

According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - Segments of bacteria and archaea DNA containing short repetitions of base sequences.

Visual similarity to commonly confused words

How many letter changes separate each confused pair (Levenshtein distance, normalized).

CRISPR vs Crist
17% similar
CRISPR vs crispy
0% similar
CRISPR vs crisps
0% similar

Source: PlainSpell confusable corpus (Wiktionary, CC BY-SA).

Key facts for CRISPR
PropertyValue
HeadwordCRISPR
LanguageEnglish
Part of speechNoun
IPA/ˈkrɪspər/
Letters6
Frequency rank#44,144
Misspellings tracked10
Confusable pairs11
SourceWiktionary (kaikki.org)

Where “CRISPR” sits in English frequency

Every-word frequency runs from the handful of words we use constantly (left) to the long tail used once in a blue moon (right). CRISPR lands here:

#1#100#1K#10K#100K
← used constantlyrarely used →

Scale is logarithmic (each tick is 10× rarer). Source: FrequencyWords open word-frequency list.

Spelling & Dictionary Insight

The English entry for CRISPR is 6 letters long, classified as a noun, and transcribed in the International Phonetic Alphabet as /ˈkrɪspər/. Corpus data places it at rank #44,144 in overall English word frequency, marking it as uncommon enough that many writers pause before typing it. Wiktionary records 3 distinct senses for this headword, so context determines which meaning a reader should apply.

Our generated misspelling index lists 10 likely wrong-spelling variants for CRISPR, with forms such as "ccrispr", "cirspr", and "cripsr". Every one of these variants traces to a single-character edit -- an added or dropped letter, a swapped consonant, or a vowel swap -- the kind of slip a spell-checker is built to catch. It also participates in 11 confusable-pair relationships, "Crist", "crispy", "crisps", and more, a pairing that trips writers up because the two words share enough sound or shape to blur together.

Etymologically, the entry records: Acronym of clustered, regularly interspaced short palindromic repeats. The correct English form is CRISPR, spelled C-R-I-S-P-R.

Definition

  1. 1
    Segments of bacteria and archaea DNA containing short repetitions of base sequences.
  2. 2
    The CRISPR/Cas9 system, which functions to provide immunity to bacteria and archaea by finding a section of DNA and replacing it with an alternative.
  3. 3
    Any technique or process or system for editing genomes by laboratory use of the CRISPR/Cas9 system.

Etymology

Acronym of clustered, regularly interspaced short palindromic repeats.

Common misspellings

Also misspelled as: ccrispr,cirspr,cripsr,crisppr,crisprr,crisrp,crisspr,crrispr,crsipr,rcispr

Misspelling Pattern Breakdown

How far each generated variant is from the correct spelling of CRISPR - measured in single-character edits (insert, delete, or substitute a letter). Larger bars are easier to catch; one-edit slips are the sneakiest.

ccrispr1cirspr2cripsr2crisppr1crisprr1crisrp2crisspr1crrispr1
Edit distance from "CRISPR"

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "CRISPR"?
"CRISPR" is spelled C-R-I-S-P-R. The IPA pronunciation is /ˈkrɪspər/.
What does "CRISPR" mean?
As a noun, "CRISPR" means: Segments of bacteria and archaea DNA containing short repetitions of base sequences.
What words are commonly confused with "CRISPR"?
"CRISPR" is commonly confused with "Crist", "crispy", "crisps". These words look or sound similar but have different meanings. PlainSpell provides detailed comparisons for each pair.
How do you pronounce "CRISPR"?
The IPA (International Phonetic Alphabet) transcription for "CRISPR" is /ˈkrɪspər/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.
What is the origin of the word "CRISPR"?
Acronym of clustered, regularly interspaced short palindromic repeats. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Using “CRISPR”

The practical upshot for anyone who landed here from a spell-check.

  • The one correct English spelling is C-R-I-S-P-R - every other letter order is a misspelling in standard orthography.
  • Say it as /ˈkrɪspər/ (IPA); tap the speaker on the pronunciation badge to hear it where audio exists.
  • Don't mix it up with “Crist” - see the side-by-side comparison. CRISPR vs Crist
  • Browse more English words and confusable pairs in the same reference. English words
Data Source

Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list FrequencyWords open word-frequency list