amitriptyline

/æmɪˈtɹɪptɪliːn/

//æmɪˈtɹɪptɪliːn// noun

"amitriptyline" is a 13-letter English headword indexed on PlainSpell.

The verdict

“amitriptyline” is uncommon English (frequency #86,008 among 3,931 “A” headwords), classed as a noun. The kind of spelling people second-guess.

#86,008
frequency rank, English
3,931
“A” headwords

According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - An antidepressant drug; a tablet containing this drug.

Corpus desk

Index EN-amitriptyline · amitriptyline · English

amitriptyline · rank #86,008 · 0 variants · 0 confusables

  • FREQ-RARE #86,008
  • LEN-MEGA 13 letters
  • VOW-6 6 vowels
  • CONFUS-0 No pairs
  • VAR-0 0 variants
  • BOOK-MID 3,931
  • PHOTO-FINISH Amhara

Nearest frequency peer: Amhara (-1 rank slots)

Read with this headword: Spelling guide for this pattern

Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.

Long-tail ranks near “amitriptyline”

Sparse band: bars invert rank so rarer forms read shorter

corpus weight

What this shows Long-tail view: where “amitriptyline” sits against similarly uncommon English ranks.

Source FrequencyWords open word-frequency list As of September 3, 2026
Key facts for amitriptyline
PropertyValue
Headwordamitriptyline
LanguageEnglish
Part of speechNoun
IPA/æmɪˈtɹɪptɪliːn/
Letters13
Frequency rank#86,008
Misspellings tracked0
Confusable pairs0
SourceWiktionary (kaikki.org)

Long-tail rank of “amitriptyline” in English

This scale runs from the tiny cluster of words that carry ordinary speech (left) to the long tail of words almost nobody reaches for (right).amitriptylinefalls in this rarity band:

#1#100#1K#10K#100K
← used constantlyrarely used →

Scale is logarithmic (each tick is 10× rarer). Rare peers in the same band: “Amhara” (#86,007), “amparo” (#86,009), “aniseed” (#86,011). Among 3,931 “A” headwords, “amitriptyline” is #86,008. Source: FrequencyWords open word-frequency list.

Rare enough to double-check

amitriptyline is uncommon English at frequency #86,008 among 3,931 “A” headwords, classed as anoun, transcribed /æmɪˈtɹɪptɪliːn/. Rarity is why readers land here mid-draft. Gloss: "An antidepressant drug; a tablet containing this drug.".

No generated misspelling entries exist for amitriptyline in our index, a sign its spelling follows regular English conventions. Our confusable-pair dataset has no match for it, which usually means its spelling is distinct enough that readers don't reach for a similar-looking word instead.

Etymologically, the entry records: From ami(no-) + tri- + (he)ptyl + -ine. The correct English form is amitriptyline, spelled A-M-I-T-R-I-P-T-Y-L-I-N-E.

Definition

  1. 1
    An antidepressant drug; a tablet containing this drug.

Recorded use

Wiktionary example

These source excerpts show how amitriptyline appears in context. They illustrate usage; the definition above remains the entry’s reference meaning.

  1. ‘They were in very low concentrations, only fifteen per cent of the total. The remaining eighty-five per cent was made up of a powerful tranquillizer, amitryptiline.’

Etymology

From ami(no-) + tri- + (he)ptyl + -ine.

Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.

Frequently Asked Questions

How do you spell "amitriptyline"?
"amitriptyline" is spelled A-M-I-T-R-I-P-T-Y-L-I-N-E. The IPA pronunciation is /æmɪˈtɹɪptɪliːn/.
What does "amitriptyline" mean?
As a noun, "amitriptyline" means: An antidepressant drug; a tablet containing this drug.
How do you pronounce "amitriptyline"?
The IPA (International Phonetic Alphabet) transcription for "amitriptyline" is /æmɪˈtɹɪptɪliːn/. Click the speaker icon on the pronunciation badge above to hear it spoken aloud where audio is available.
What is the origin of the word "amitriptyline"?
From ami(no-) + tri- + (he)ptyl + -ine. See the full etymology section above for more details.
Is PlainSpell free to use?
Yes, PlainSpell is a completely free word reference. You can look up definitions, pronunciations, confusable pairs, homophones, and spelling corrections across 5 languages without any sign-up or subscription.

Similar English words by spelling shape

Same letter count and similar misspelling depth for "amitriptyline", not the corpus desk frequency band.

Same letter count

Frequency-ranked English headwords with 13 letters (nearest by frequency rank).

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list