downregulation
"downregulation" is a 14-letter English headword indexed on PlainSpell.
The verdict
“downregulation” is an uncommon English word, ranked #98,039 in English word frequency and used as a noun.
- #98,039
- frequency rank, English
- 14
- letters
According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - The suppression of a response to a stimulus
| Property | Value |
|---|---|
| Headword | downregulation |
| Language | English |
| Part of speech | Noun |
| Letters | 14 |
| Frequency rank | #98,039 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Where “downregulation” sits in English frequency
Spelling & Dictionary Insight
The English entry for downregulation is 14 letters long, classified as a noun. Corpus data places it at rank #98,039 in overall English word frequency, marking it as uncommon enough that many writers pause before typing it. Wiktionary records 2 distinct senses for this headword, so context determines which meaning a reader should apply.
Our edit-distance generator produced no likely misspellings for downregulation, a straightforward case of a spelling with little room for common typos. Our confusable-pair dataset has no match for it, a sign it's visually distinctive enough not to be mixed up with another word.
Etymologically, the entry records: From down- + regulation. The correct English form is downregulation, spelled D-O-W-N-R-E-G-U-L-A-T-I-O-N.
Definition
- 1The suppression of a response to a stimulus
- 2The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity
Etymology
From down- + regulation.
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
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Using “downregulation”
The practical upshot for anyone who landed here from a spell-check.
- The one correct English spelling is D-O-W-N-R-E-G-U-L-A-T-I-O-N - every other letter order is a misspelling in standard orthography.
- Browse more English words and confusable pairs in the same reference. English words
Data Source
Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.