downregulation
"downregulation" is a 14-letter English headword indexed on PlainSpell.
The verdict
“downregulation” is uncommon English (frequency #98,039 among 3,470 “D” headwords), classed as a noun. The kind of spelling people second-guess.
- #98,039
- frequency rank, English
- 3,470
- “D” headwords
According to Wiktionary data (CC BY-SA, analyzed September 3, 2026) - The suppression of a response to a stimulus
Corpus desk
Index EN-downregulation · downregulation · English
downregulation · rank #98,039 · 0 variants · 0 confusables
- FREQ-RARE #98,039
- LEN-MEGA 14 letters
- VOW-6 6 vowels
- CONFUS-0 No pairs
- VAR-0 0 variants
- BOOK-MID 3,470
- PHOTO-FINISH downshift
Nearest frequency peer: downshift (+1 rank slots)
Read with this headword: Spelling guide for this pattern
Desk codes from Wiktionary headword shape, FrequencyWords rank tier, confusable-pair count, generated misspelling depth, letter-cohort book size, and photo-finish peer. Not a difficulty grade.
Long-tail ranks near “downregulation”
Sparse band: bars invert rank so rarer forms read shorter
- discomforti…
discomforting
1,968 corpus weight
- disjunctive
disjunctive
1,967 corpus weight
- divo
divo
1,966 corpus weight
- downregulat…
downregulation
1,962 corpus weight
- downshift
downshift
1,961 corpus weight
- drily
drily
1,958 corpus weight
What this shows Long-tail view: where “downregulation” sits against similarly uncommon English ranks.
| Property | Value |
|---|---|
| Headword | downregulation |
| Language | English |
| Part of speech | Noun |
| Letters | 14 |
| Frequency rank | #98,039 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Long-tail rank of “downregulation” in English
Rare enough to double-check
downregulation is uncommon English at frequency #98,039 among 3,470 “D” headwords, classed as anoun. Rarity is why readers land here mid-draft. 2 senses are on record.
Our edit-distance generator produced no likely misspellings for downregulation, a straightforward case of a spelling with little room for common typos. Our confusable-pair dataset has no match for it, a sign it's visually distinctive enough not to be mixed up with another word.
Etymologically, the entry records: From down- + regulation. The correct English form is downregulation, spelled D-O-W-N-R-E-G-U-L-A-T-I-O-N.
Definition
- 1The suppression of a response to a stimulus
- 2The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity
Etymology
From down- + regulation.
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
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Similar English words by spelling shape
Same letter count and similar misspelling depth for "downregulation", not the corpus desk frequency band.
Same letter count
Frequency-ranked English headwords with 14 letters (nearest by frequency rank).