choline
/ˈkoʊliːn/
"choline" is a 7-letter English headword indexed on PlainSpell.
The verdict
“choline” is uncommon English (frequency #55,325 among 43,570 “C” headwords), classed as a noun. The kind of spelling people second-guess.
- #55,325
- frequency rank, English
- 43,570
- “C” headwords
According to Wiktionary data (CC BY-SA, analyzed May 6, 2026) - A hydroxy quaternary ammonium compound with formula (CH₃)₃N⁺CH₂CH₂OHX⁻. It is an essential nutrient for cardiovascular and brain health and for cell membrane formation.
| Property | Value |
|---|---|
| Headword | choline |
| Language | English |
| Part of speech | Noun |
| IPA | /ˈkoʊliːn/ |
| Letters | 7 |
| Frequency rank | #55,325 |
| Misspellings tracked | 0 |
| Confusable pairs | 0 |
| Source | Wiktionary (kaikki.org) |
Where “choline” sits in English frequency
Rare enough to double-check
choline is uncommon English at frequency #55,325 among 43,570 “C” headwords, classed as anoun, transcribed /ˈkoʊliːn/. Rarity is why readers land here mid-draft. Gloss: "A hydroxy quaternary ammonium compound with formula (CH₃)₃N⁺CH₂CH₂OHX⁻. It is an essential nutrient for cardiovascular and brain health and for cell membrane formation.".
choline doesn't appear in our generated misspelling index, suggesting the orthography follows predictable English patterns. No close-neighbour confusable shows up for this headword in our dataset, which tends to mean the word is visually distinctive enough to stand on its own.
Etymologically, the entry records: Coined from Ancient Greek χολή (kholḗ, “bile”). The chemical compound was first isolated by Adolph Strecker from pig and ox bile (hence the name) in 1862. It was also named neurine when chemically synthesized by Oscar Liebreich in 1865, until 1898 when show… The correct English form is choline, spelled C-H-O-L-I-N-E.
Definition
- 1A hydroxy quaternary ammonium compound with formula (CH₃)₃N⁺CH₂CH₂OHX⁻. It is an essential nutrient for cardiovascular and brain health and for cell membrane formation.
Etymology
Coined from Ancient Greek χολή (kholḗ, “bile”). The chemical compound was first isolated by Adolph Strecker from pig and ox bile (hence the name) in 1862. It was also named neurine when chemically synthesized by Oscar Liebreich in 1865, until 1898 when shown to be identical to choline.
Synonyms
This word in other languages
Definitions, pronunciation, and etymology for this entry are drawn from Wiktionary via the kaikki.org structured extract (CC BY-SA); frequency ordering uses the FrequencyWords open word-frequency list (2018 English corpus, MIT). See the methodology for how each field is sourced and updated.
Frequently Asked Questions
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Using “choline”
The practical upshot for anyone who landed here from a spell-check.
- The one correct English spelling is C-H-O-L-I-N-E - every other letter order is a misspelling in standard orthography.
- Say it as /ˈkoʊliːn/ (IPA); tap the speaker on the pronunciation badge to hear it where audio exists.
- Browse more English words and confusable pairs in the same reference. English words
Other uncommon English words near this rank
Data Source
Wiktionary (via kaikki.org), licensed under CC BY-SA & GFDL. Word ordering uses an open word-frequency list; misspelling variants are generated by edit-distance from the correct headword.