# Van Wyk and Grumbach syndrome

> English word · Noun

## Definitions
1. A medical condition involving hypothyroidism, precocious puberty (with delayed bone age and lack of pubic hair), and ovarian cysts in pre- and post-pubertal girls or macroorchidism in boys.

## Etymology
Described in 1960 by Van Wyk and Melvin M. Grumbach.

## Source
Compiled from Wiktionary via kaikki.org (CC BY-SA). Data vintage: 2026-05-06.
Canonical page: https://plainspell.com/en/word/van-wyk-and-grumbach-syndrome