# topoisomerase

> English word · Noun · IPA /ˌtɒpəʊˌaɪˈsɒməˌɹeɪs/

## Definitions
1. Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.

## Etymology
From topo- + isomerase.

## Source
Compiled from Wiktionary via kaikki.org (CC BY-SA). Data vintage: 2026-05-06.
Canonical page: https://plainspell.com/en/word/topoisomerase