# methotrexate

> English word · Noun · IPA /ˌmɛθ.əˈtɹɛk.seɪt/ · frequency rank #54,333

## Definitions
1. An antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases, and ectopic pregnancies.

## Etymology
Probably from metho- + tre- (“alteration of pteridine”) + (carbo)x(yl)ate.

## Source
Compiled from Wiktionary via kaikki.org (CC BY-SA). Data vintage: 2026-05-06.
Canonical page: https://plainspell.com/en/word/methotrexate