# in silico

> English word · Prep_phrase · IPA /ɪn ˈsɪlɪkəʊ/

## Definitions
1. In computer simulation or in virtual reality.

## Etymology
From in and silicon (from Latin silex (“flint, pebble, stone; crag, rock”)) + Latin -ō, by analogy with English in vitro (“in glass, referring to an experiment conducted in a test tube”). The silico component refers to silicon chips which were used for computing at the time when the term was coined.

## Source
Compiled from Wiktionary via kaikki.org (CC BY-SA). Data vintage: 2026-05-06.
Canonical page: https://plainspell.com/en/word/in-silico