# downtitration

> English word · Noun

## Definitions
1. The gradual reduction of a dose accompanied by observation of effects, usually and especially to arrive at an optimal dose.

## Etymology
From down- + titrate; compare also upregulation and downregulation.

## Source
Compiled from Wiktionary via kaikki.org (CC BY-SA). Data vintage: 2026-05-06.
Canonical page: https://plainspell.com/en/word/downtitration