# downregulation

> English word · Noun · frequency rank #98,039

## Definitions
1. The suppression of a response to a stimulus
2. The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity

## Etymology
From down- + regulation.

## Source
Compiled from Wiktionary via kaikki.org (CC BY-SA). Data vintage: 2026-05-06.
Canonical page: https://plainspell.com/en/word/downregulation