interferevsinterferonWhich spelling fits?

Quick tell: interfere is a verb, interferon is a noun, so they fill different roles in a sentence.

Which to use

“interfere” is a verb and “interferon” is a noun - they look or sound alike but fill different roles in a sentence.

#8,559
“interfere” frequency rank
#38,912
“interferon” frequency rank
47471
confusion score

Side-by-Side Comparison

Feature interfere interferon
Definition To get involved or involve oneself, causing disturbance. Any of a group of glycoproteins, produced by the immune system, that prevent viral replication in infected cells.

Where the eye mixes interfere and interferon

Muted = shared; highlighted = the visual trap. They share 8 letters in sequence.

9 ch
interfere
10 ch
interferon

Visual trap between interfere and interferon

These two trip readers on the page rather than in the ear: interfere is /ˌɪn.tɚˈfɪɚ/ while interferon is /ˌɪn.təˈfɪːˌɒn/. Spoken aloud the problem disappears. In writing it persists, because they differ by 1 letter(s) in length, and the parts of speech differ too (verb vs noun), which is usually the fastest check. Our composite confusion score for this pair is 47471, derived from the frequency rank of both members and their visual similarity.

interfere is recorded at frequency rank #8,559, classified as averb, pronounced /ˌɪn.tɚˈfɪɚ/. interferon is at rank #38,912, tagged as anoun, pronounced /ˌɪn.təˈfɪːˌɒn/.

Glosses for this pair are partially populated in our dataset, but the full side-by-side definitions above should still guide you to the right choice.

With a confusion score of 47471, this pair ranks #202,119 of 530,003 scored English confusable pairs - roughly mid-pack for confusability.

Orthographic DNA of interfere vs interferon

Shared letters: efinrt. Private to "interfere": -. Private to "interferon": o.

"interfere" · 9 letters · shape VCCVCCVCV  ·  "interferon" · 10 letters · shape VCCVCCVCVC

Known mistypes of this pair

  • interfereinetrfere · innterfere · intefrere · interefre · interfeer · interferre · interffere · interfree
  • interferoninetrferon · innterferon · intefreron · interefron · interfeorn · interferno · interferonn · interferron

Frequently Asked Questions

Do "interfere" and "interferon" mean the same thing in a sentence?
No - they are not even the same part of speech. "interfere" is a verb and "interferon" a noun, so a sentence built for one is usually ungrammatical with the other.
Which is more common, "interfere" or "interferon"?
"interfere" is the more common of the two: it sits at frequency rank #8,559 in our English list, against #38,912 for "interferon". The two are close in frequency, so neither is a safe default; check the meaning rather than guessing.

After this comparison

Pronunciation already separates them, if the page still looks alike, the dictionary links below settle it.

  • Full dictionary entry for "interfere" with definition, IPA, and generated misspellings. Word entry
  • Full dictionary entry for "interferon" - compare definitions side by side with the headword page. Word entry
  • This pair ranks #202,119 of 530,003 scored English confusable pairs in this corpus vintage. Corpus statistics
  • "interfere" and "interferon" also get mixed up with nearby pairs, the highest-scored neighbour is "interfered vs interferon". Nearby pair
  • Recorded mistypes exist for at least one side of this pair, useful when a spell-checker or OCR lands on the wrong form. See mistypes

Confusion rank #202,119 of 530,003 scored English pairs, corpus vintage 2026-09-03, not spelling advice.

Source: Wiktionary (via kaikki.org) Structured Wiktionary extract

Source: FrequencyWords open word-frequency list